Aesthetic Improvement of Facial Rhytids Using Injectables

Revanesse® Renew™+ (Prollenium Medical Technologies Inc.) is a non-crosslinked HA skin booster that combines low- and high-molecular-weight HA at a concentration of 14 mg/mL in a sterile aqueous gel for intradermal injection7. This dual-weight formulation provides both rapid hydration and sustained moisture retention, improving dermal suppleness and promoting subtle textural refinement through physiologic hydration rather than volumization. The present study is designed to compare biweekly and monthly treatment schedules of Revanesse® Renew™+, assessing clinical efficacy, objective biophysical markers, and participant-reported outcomes to inform evidence-based treatment protocols in aesthetic medicine.

NCT Number	NCT07383766
Lead Sponsor	Erevna Innovations Inc.
Conditions	Aesthetic
Enrollment	14 participants
Start Date	2026-03-14
Primary Completion	2026-06-04 (estimated)
Study Completion	2026-08-04 (estimated)
Updated on ClinicalTrials.gov	2026-08-05