Molecular Determinants of Spinal Cord Injury Rehabilitation

This study main aim is to identify molecular determinants of better recovery following spinal cord injury (SCI), as biomarkers of neurological and/or functional improvement and a proxy for neuroregeneration. For that, omics analyses of several biological samples will be performed, to comprehensively portray the molecular and cellular profiles of the patients with SCI at key time points of the pathology: pre-rehabilitation, post-rehabilitation and one-year post-injury. The main question it aims to answer is: 'Are there specific molecules (and related biological pathways) that impact the functional recovery of spinal cord injury patients during the subacute phase, in a way that future targeted pharmacological or genetic interventions may improve SCI outcomes?'.

NCT Number	NCT07383077
Lead Sponsor	Prof. Sandra Vieira Collaborators: Aveiro Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Centro de Reabilitacao do Norte, Unidade Local de Saude de Gaia e Espinho EPE, Centro Academico Clínico Egas Moniz Health Alliance
Conditions	Spinal Cord Injury
Enrollment	106 participants
Start Date	2021-05-01
Primary Completion	2023-10-16 (estimated)
Study Completion	2023-10-16 (estimated)
Updated on ClinicalTrials.gov	2026-02-03