Clinical Trial

Preventing Neurologic Complications in Valve Surgery

Not Yet Recruiting
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Summary
In patients with valvular heart disease and atrial fibrillation (AF) undergoing surgical valve surgery, current guidelines recommend concomitant surgical management of the left atrial appendage (LAA) to prevent postoperative thromboembolic events, particularly neurologic embolic events. However, whether concomitant LAA management benefits patients without AF by reducing postoperative neurologic complications remains controversial. Given these uncertainties, this study aims to evaluate whether concomitant LAA suture closure during surgical valve surgery is associated with a lower incidence of perioperative silent cerebral infarction.
Trial Details
NCT Number NCT07382362
Lead Sponsor China National Center for Cardiovascular Diseases
Conditions Left Atrial Appendage Closure
Enrollment 100 participants
Start Date 2026-01-27
Primary Completion 2028-01-31 (estimated)
Study Completion 2028-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-02