Biomarkers of Brain Injury in Children With Brain Tumors

The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors. The main question it aims to answer is: Can investigators identify sensitive plasma biomarker(s) of treatment-induced brain injury in children with primary brain tumors? Researchers will compare results between different treatment modalities (surgery, chemotherapy, radiation versus radiation-naive) and a healthy age- and sex-matched control population, to identify treatment-specific biomarkers. Participants will provide plasma samples at the following time points: before surgery, 1-2 weeks after surgery, as well as at 3-, 6-, 12-, 18-, 24-, and 36 months after surgery. Participants who receive radiation treatment will also provide plasma samples before and during treatment (approximately every 2 weeks). Where possible, plasma samples are also collected before the start of any new treatment (e.g., chemotherapy). Healthy controls will provide samples once.

NCT Number	NCT07381959
Lead Sponsor	Uppsala University Collaborators: Region Blekinge, Region Dalarna, Region Gotland, Region Gävleborg, Region Uppsala, Region Halland, Region Jämtland Härjedalen, Region Jönköping County, Region Kalmar län, Region Kronoberg, Region Norrbotten, Region Skane, Region Stockholm, Sormland County Council, Sweden, Region Värmland, Region Västerbotten, Region Västernorrland, Region Västmanland, Region Örebro län, Region Östergotland, Göteborg University, Västra Götalandsregionen
Conditions	Brain Tumor, Childhood Cancer, Childhood Brain Tumor
Enrollment	560 participants
Start Date	2021-08-01
Primary Completion	2031-12-31 (estimated)
Study Completion	2031-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-02