Focused Ultrasound Treatment for Facial Skin Laxity

The goal of this clinical trial is to learn if focused ultrasound can improve facial skin laxity in adults. The main questions this study aims to answer are: 1. Does focused ultrasound treatment lead to clinically meaningful improvement in facial skin laxity compared with baseline assessments? 2. What treatment-related adverse events occur following focused ultrasound treatment, and how frequently and severely do they occur? Researchers will also compare outcomes between the two sides of the face treated with different focused ultrasound hand-pieces within the same participants to explore potential differences in clinical response and safety using a randomized split-face design. Participants will: Receive a single session of focused ultrasound treatment applied to both sides of the face. Undergo standardized clinical assessments, imaging evaluations, and patient-reported outcome measures at baseline and during follow-up visits. Be monitored for treatment-related adverse events throughout the study period.

NCT Number	NCT07381218
Lead Sponsor	The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Conditions	Facial Skin Laxity, Skin Aging
Enrollment	19 participants
Start Date	2025-07-03
Primary Completion	2026-03-14 (estimated)
Study Completion	2026-03-14 (estimated)
Updated on ClinicalTrials.gov	2026-04-21