VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site

This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to: 1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection; 2. compare proximal and distal sample results obtained from an external ventricular drain; 3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.

NCT Number	NCT07380477
Lead Sponsor	Rigshospitalet, Denmark
Conditions	Acute Brain Injury, Hydrocephalus, External Ventricular Drain, External Ventricular Drainage Associated Infection
Enrollment	148 participants
Start Date	2025-01-15
Primary Completion	2027-01-15 (estimated)
Study Completion	2029-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-02