Clinical Trial

Acute Neurochemical and Cognitive Changes After HIIT vs MICT/LICT

Study acronym: ANCCR
Completed
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Summary
This study examines whether the intensity of a single running session changes a blood marker related to brain health (brain-derived neurotrophic factor, BDNF), blood lactate, and performance on a short thinking task that measures attention and self-control (the Stroop test) in healthy young adult men. Twelve healthy males (18-25 years) will complete four separate sessions in a randomized, counterbalanced order, with at least 7 days between sessions. Each session includes an 8-minute warm-up followed by 24 minutes of one of the following conditions: low-intensity continuous running, moderate-intensity continuous running, high-intensity interval running (repeated 15-second fast runs with 15-second passive rest, organized into sets), or a seated rest control session. Running pace will be individualized based on a prior fitness test. A small venous blood sample (about 8 mL) will be collected immediately before and within 1 minute after each session. After each session, participants will complete the Stroop test. The main outcomes are the before-to-after changes in serum BDNF, blood lactate, and Stroop test performance across the four conditions.
Trial Details
NCT Number NCT07379879
Lead Sponsor Aksaray University Training and Research Hospital
Conditions BDNF, Cognitive Performance, Lactate, Exercise Intensity
Enrollment 12 participants
Start Date 2025-08-01
Primary Completion 2025-09-20 (estimated)
Study Completion 2025-09-25 (estimated)
Updated on ClinicalTrials.gov 2026-02-02