Impact of Positive Bile Cultures on Plastic Biliary Stent Exchange

This prospective, unicenter, randomized controlled trial evaluates whether a positive bile culture at index ERCP with plastic stenting identifies patients who benefit from earlier stent exchange. Patients with no previous history of sphincterotomy and positive bile cultures after an ERCP will be randomized to stent exchange at 1 month versus 3 months to assess whether personalized scheduling reduces early stent occlusion and secondary acute cholangitis.

NCT Number	NCT07379749
Lead Sponsor	Clinical Hospital Colentina
Conditions	Acute Cholangitis
Enrollment	140 participants
Start Date	2026-02
Primary Completion	2026-12 (estimated)
Study Completion	2027-02 (estimated)
Updated on ClinicalTrials.gov	2026-01-30