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Proactive Temperature Management in CRS-HIPEC for Prevention of Delirium

StatusNot Yet Recruiting
PhaseNot applicable
Started
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Record status
This record was last updated January 30, 2026 (before its estimated March 20, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Study First Submitted
This randomized controlled trial evaluates the efficacy of a proactive Goal-Directed Temperature Management (GDTM) protocol in reducing postoperative delirium among patients undergoing Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for pseudomyxoma peritonei. CRS-HIPEC presents a unique physiological challenge characterized by a biphasic thermal trajectory: potential hypothermia during extensive surgery followed by rapid iatrogenic hyperthermia during perfusion. This study compares a standardized GDTM strategy-which incorporates strict normothermia maintenance and anticipatory pre-cooling prior to perfusion-against standard reactive thermal management. The primary objective is to determine if optimized thermoregulation can attenuate thermal variability and improve early neurocognitive recovery.
Trial Details
NCT Number NCT07378371
Lead Sponsor Aerospace Center Hospital
Conditions
(from sponsor)		 Pseudomyxoma Peritonei, Postoperative Delirium (POD)
Related terms Emergence Delirium, Pseudomyxoma Peritonei
Enrollment 174 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov