Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers

This Phase I randomized clinical trial aims to investigate the short-term effects of three commonly prescribed statins (atorvastatin, rosuvastatin, and simvastatin) at different dose levels on blood glucose homeostasis in healthy volunteers. The study will assess changes in fasting blood glucose, insulin, and C-peptide levels following two days of statin administration under controlled conditions. The research seeks to provide comparative data on the potential diabetogenic effects of these medications.

NCT Number	NCT07378293
Lead Sponsor	Shaheed Benazir Bhutto University Sheringal Dir Upper Collaborators: Khyber Medical University Peshawar
Conditions	Diabete Mellitus, Lipid Profile
Enrollment	100 participants
Start Date	2026-03-01
Primary Completion	2026-12-30 (estimated)
Study Completion	2027-02-20 (estimated)
Updated on ClinicalTrials.gov	2026-01-30