Aerobic Exercise vs Physiological Ischemic Training in Stage 2 Hypertension

This study aims to compare the effects of aerobic exercise (AE) and physiological ischemic training (PIT) on inflammatory and angiogenesis biomarkers (VEGF, IL-6, IL-10), cardiorespiratory fitness, muscle strength, and quality of life in patients with grade 2 primary hypertension (HT2). This randomized controlled trial will involve 60 HT2 patients from Pratama and Utama Medika Antapani Clinic, who will be assigned to either AE or PIT groups. The intervention will last 6 weeks, and outcomes measured will include biomarker levels, VO2max, 6-minute walk distance (6-MWD), maximum voluntary contraction (MVC), and SF-36 questionnaire scores.

NCT Number	NCT07375407
Lead Sponsor	Universitas Padjadjaran
Conditions	Primary Hypertension, Grade 2
Enrollment	60 participants
Start Date	2023-08-05
Primary Completion	2023-12-05 (estimated)
Study Completion	2024-02-05 (estimated)
Updated on ClinicalTrials.gov	2026-02-02