Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress

The goal of this clinical trial is to learn whether drinking a daily serving of gazpacho can improve semen quality in men with reduced sperm quality. The study will also examine how this dietary intervention affects oxidative stress and whether it is well tolerated. The main questions this study aims to answer are: * Does daily consumption of gazpacho improve semen quality in men with altered semen parameters? * Does this dietary intervention affect levels of oxidative stress in semen? * Is daily gazpacho intake feasible and well tolerated as part of a Mediterranean diet? Researchers will compare a Mediterranean diet plus daily gazpacho intake with a Mediterranean diet alone to determine whether adding gazpacho provides additional benefits for male reproductive health. Participants will: * Follow a standardized Mediterranean diet for 12 weeks * Drink 330 mL of gazpacho every day or follow the diet without gazpacho * Provide semen samples at the start of the study and after 12 weeks * Complete a short diary to record adherence to the dietary intervention * Be followed for up to 18 months to record reproductive outcomes

NCT Number	NCT07375238
Lead Sponsor	Ginefiv Collaborators: Instituto Valenciano de Infertilidad, IVI VALENCIA
Conditions	Male Infertility, Oxidative Stress, Subfertility, Oligozoospermia, Asthenozoospermia, Teratozoospermia
Enrollment	80 participants
Start Date	2026-03-02
Primary Completion	2028-03-01 (estimated)
Study Completion	2029-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-13