Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix

This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm). Participants will be randomly allocated to either the intervention group (cerclage plus progesterone) or the control group (progesterone alone).

NCT Number	NCT07372495
Lead Sponsor	National Hospital of Obstetrics and Gynecology Collaborators: Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam, Ninh Binh Obstetrics and Pediatrics Hospital, Ninh Binh, Vietnam, Bac Ninh 1 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam, Bac Ninh 2 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam, Hung Yen Obstetrics and Pediatrics Hospital, Hung Yen, Vietnam
Conditions	Preterm
Enrollment	260 participants
Start Date	2026-04-10
Primary Completion	2028-12-30 (estimated)
Study Completion	2029-05-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-24