Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers

The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.

NCT Number	NCT07372183
Lead Sponsor	Marquette University Collaborators: LifeNet Health
Conditions	Smoking, Cigarette, Alveolar Bone Grafting, Wound Healing, Bone Healing, Tooth Extraction Site Healing
Enrollment	12 participants
Start Date	2026-01-25
Primary Completion	2028-10-01 (estimated)
Study Completion	2028-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-28