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Ketamine Irrigation Analgesia in Laparoscopic Cholecystectomy

Study acronym: Ketamine
StatusActive, Not Recruiting
PhasePhase 3
Started2026-01-30
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 4 months later Jul 1, 2026 → Nov 1, 2026
Primary endpoint added 1 → 2 primary endpoints
See other at-risk trials from Assiut University

Amendment history

2026-09-11
Study Status, Outcome Measures v2
Primary endpoint(s) modified1 to 2 entries
WasThe total consumption of rescue analgesics
NowSystemic inflammatory response via Neutrophil-to-lymphocyte ratio (NLR), The total consumption of rescue analgesics
2026-09-04
Study Status, Contacts/Locations v1
Trial status changed: Not Yet Recruiting → Active, Not Recruiting
Primary completion pushed: 2026-07-01 → 2026-11-01
Completion pushed: 2026-07-10 → 2026-11-03
Study sites0→1
2026-01-19
Original filing
Assiut University
1,604 trials monitored
See 18 trials at risk
Patients will be assigned randomly to two groups (30 subjects each) to be anesthetized. The study drug will be delivered in opaque bags labeled "study drug" and 60 patients will be allocated in two groups (of 30 patients each) to receive the irrigation at the end of surgery after dissection; irrigation analgesia by 5 ml bupivacaine 0.50% plus 20 ml normal saline (Group N) or 5 ml bupivacaine 0.50% plus 1 mg/kg ketamine (Group K). The volume of irrigation in group K is completed by normal saline to reach a total of 25 ml.
Trial Details
NCT Number NCT07370181
Lead Sponsor Assiut University
Conditions Pain
Enrollment 60 participants
Start Date 2026-01-30
Primary Completion 2026-11-01 (estimated)
Study Completion 2026-11-03 (estimated)
Updated on ClinicalTrials.gov 2026-09-15