The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function

This study aims to propose a novel, easy-to-operate intervention strategy that effectively improves defecation function after stoma reversal and to assess its impact on the gut microbiota.The efficacy and safety of antegrade placement of probiotics into the distal deserted intestine during prophylactic stoma to improve bowel function after stoma reversal were evaluated through randomized controlled clinical trials.Observing the changes in gut microbiota during the prophylactic stoma period, the impact of probiotics on the structure of gut microbiota, and exploring the correlation between gut genera and bowel function after stoma reversal.

NCT Number	NCT07369830
Lead Sponsor	Huashan Hospital Collaborators: Characteristic Medical Center of Rocket Army, Zhongnan Hospital, The Affiliated People's Hospital of Nankai University, First Affiliated Hospital of Fujian Medical University, Ruijin Hospital, Nanfang Hospital, Southern Medical University
Conditions	Rectal Cancer
Enrollment	156 participants
Start Date	2025-10-15
Primary Completion	2029-03-30 (estimated)
Study Completion	2029-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-01-27