Prospective Evaluation of Adler Laboratory's Massive Prosthetic Implants in Oncological and Non-oncological Situations

Massive prostheses are the standard treatment for extensive bone loss, whether caused by cancer or other factors (complex fractures, multiple revisions, infections). The emergence of modular systems such as the Pantheon range provides rapid restoration of function and precise intraoperative adaptation to anatomical constraints and specific bone loss characteristics. The Pantheon range also offers an innovative intramedullary ring system that promotes osseointegration and potentially long-term mechanical stability of implants. However, few studies have evaluated its clinical efficacy. In this context, a prospective cohort study is warranted in order to obtain robust data on implant survival, patient quality of life and predictors of medium- and long-term complications.

NCT Number	NCT07369778
Lead Sponsor	Nantes University Hospital
Conditions	Reconstruction of Massive Bone Loss (Oncologic and Non-oncologic)
Enrollment	375 participants
Start Date	2026-05-30
Primary Completion	2030-01-30 (estimated)
Study Completion	2036-01-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-14