Clinical Management Strategies for Patients With Cirrhosis and Esophagogastric Varices Complicated by Early-stage Upper Gastrointestinal Cancer

Managing early-stage upper gastrointestinal cancer in patients with liver cirrhosis and esophagogastric varices (EGV) poses substantial clinical challenges. Although endoscopic submucosal dissection (ESD) is an established treatment for these early cancers, its efficacy and safety in this high-risk population are poorly defined. Therefore, this study aims to investigate optimal screening and treatment strategies for early-stage upper gastrointestinal cancer in cirrhotic patients with EGV. Perioperative outcomes were compared between the two groups.

NCT Number	NCT07368309
Lead Sponsor	Renmin Hospital of Wuhan University Collaborators: Southwest Hospital, China, Shanxi Coal Central Hospital, Beijing Friendship Hospital, The Second Affiliated Hospital of Chongqing Medical University, Tongji Hospital Affiliated to Tongji Medical College of HUST, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Conditions	Cirrhosis, Esophagogastric Varices, Early-stage Upper Gastrointestinal Cancer
Enrollment	206 participants
Start Date	2023-08-01
Primary Completion	2024-08-01 (estimated)
Study Completion	2025-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-26