Clinical Trial

Histatin-1 Levels in Smokers and Non-smokers With Periodontitis Patients: A Comparative Study Before and After Nonsurgical Periodontal Therapy

Study acronym: NSPT
Enrolling by Invitation
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Record status
This record was last updated January 26, 2026 (before its estimated January 29, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study evaluated the impact of smoking on salivary histatin-1 levels and clinical healing in 50 patients with unstable periodontitis (25 smokers and 25 non-smokers) undergoing non-surgical periodontal therapy (NSPT). By measuring clinical parameters like probing depth and clinical attachment level alongside ELISA-based protein analysis at baseline, one month, and three months post-treatment, the researchers sought to determine if the impaired wound healing typically seen in smokers correlates with a suppressed expression of this specific salivary protein.
Trial Details
NCT Number NCT07367737
Lead Sponsor University of Baghdad
Conditions Periodontitis, Periodontal Diseases
Enrollment 50 participants
Start Date 2025-05-01
Primary Completion 2026-01-29 (estimated)
Study Completion 2026-02-10 (estimated)
Updated on ClinicalTrials.gov 2026-01-26