Zinc Supplementation and Infections in Older Medical Patients

The goal of this clinical trial is to learn about the effect of zinc supplementation once daily for 12 months in older acute medical patients. The main question it aims to answer is: • Can daily zinc supplementation for 12 months increase Days Alive and Out of Hospital (DAOH)? Researchers will compare zinc supplementation to a control group, a group who do not receive zinc supplementation, to see if zinc supplementation can increase Days Alive and Out of Hospital, reduce antibiotic use, readmissions and mortality. Participants will take 22 mg zinc supplementation once daily for 12 months or not. The researchers will draw data on readmissions, antibiotic use and mortality during the 12 months follow-up period.

NCT Number	NCT07367412
Lead Sponsor	Herlev Hospital Collaborators: Independent Research Fund Denmark, The Novo Nordic Foundation
Conditions	Older Adults (65 Years and Older), Medical Patients in the Emergency Department
Enrollment	8,000 participants
Start Date	2026-02-01
Primary Completion	2028-03-15 (estimated)
Study Completion	2028-03-15 (estimated)
Updated on ClinicalTrials.gov	2026-05-29