Clinical Trial

The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.

Enrolling by Invitation Phase 4
View on ClinicalTrials.gov →
Summary
This study will investigate whether a combination of three anesthetic medications will reduce intraoperative and postoperative pain in patients undergoing complex spine surgery, and whether it will reduce the use of opioid pain medication after surgery.
Protocol Amendment History 1 change
critical Trial status changed: Not Yet Recruiting → Enrolling by Invitation 2026-06-12
Trial Details
NCT Number NCT07365800
Lead Sponsor University of Missouri-Columbia
Conditions Spine Surgery
Enrollment 248 participants
Start Date 2026-04-24
Primary Completion 2026-12 (estimated)
Study Completion 2027-06 (estimated)
Updated on ClinicalTrials.gov 2026-06-11