Clinical Trial

Liver Cirrhosis Complicated by Clinically Significant Portal Hypertension

Study acronym: CIRCE
Not Yet Recruiting
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Record status
This record was last updated January 26, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
Portal hypertension is a major complication of cirrhosis. HVPG is the diagnostic gold standard but is invasive. Non-invasive tools such as spleen stiffness measurement (SSM) and CEUS show promise for assessing CSPH, though they have not yet been compared directly. A multimodal ultrasound approach may provide a reliable alternative to HVPG.
Trial Details
NCT Number NCT07365709
Lead Sponsor Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions Portal Hypertension, Spleen Disease, Cirrhosis
Enrollment 107 participants
Start Date 2026-02-01
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-01-26