Fatigue and Cognitive Dysfunction Due to Synaptopathy or Graft Versus Host (GVH) Disease in the Brain.

Patients undergoing allogenic stem cell transplantation are regularly followed up in the outpatient clinic at Karolinska University Hospital. Here, patients are offered participation the fatigue study measuring both fatigue and cognitive impairment systematically by international standard. Meanwhile liquor samples and advanced PET imaging techniques are available for these patients as part of a research project allowing extensive immunological and radio-morphological studies.

NCT Number	NCT07365696
Lead Sponsor	Karolinska University Hospital Collaborators: Karolinska Institutet
Conditions	Fatigue, Graft Vs Host Disease, Cognitive Dysfunction
Enrollment	30 participants
Start Date	2023-11-28
Primary Completion	2027-12-28 (estimated)
Study Completion	2028-12-28 (estimated)
Updated on ClinicalTrials.gov	2026-01-26