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Platelet-Derived Growth Factors to Enhance Healing and Reduce Post-Extraction Complications in Smokers

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 13, 2026 (before its estimated September 30, 2026 completion). Its status may not reflect the trial's current state.
Trial flagged as At Risk
Primary completion moved at least 4 months later May 31, 2026 → Sep 30, 2026
See other at-risk trials from King Abdulaziz University

Record History

  1. Trial status changed: Not Yet Recruiting → Active, Not Recruiting
    • Primary completion pushed from May 31, 2026 to Sep 30, 2026
    • Study completion pushed from Jun 30, 2026 to Oct 30, 2026
    • Start date changed from estimate of Jan 31, 2026 to Feb 12, 2026
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study is a randomized controlled clinical trial with a split-mouth design to evaluate the effect of Advanced Platelet-Rich Fibrin (A-PRF) application on socket healing following dental extractions in smokers. In the split-mouth design, each participant serves as their own control, minimizing inter-subject variability and controlling for potential confounders such as smoking habits, oral hygiene, and systemic health conditions. Bilateral tooth extractions will be performed for each participant, with one extraction site randomly assigned to receive socket preservation using an A-PRF plug, while the contralateral site will be left to heal naturally without intervention. The study will be conducted at the Faculty of Dentistry and the University Dental Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. Recruitment began in December 2025 and will continue until the targeted sample size is achieved.
Trial Details
NCT Number NCT07364890
Lead Sponsor King Abdulaziz University
Conditions
(from sponsor)		 Smoke Exposure
Enrollment 12 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov