Clinical Trial

Autologous Transplantation of Human Cryopreserved Testis Tissue

Study acronym: ReSTORE
Active, Not Recruiting
View on ClinicalTrials.gov →
Summary
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility. This experimental clinical study aims to provide proof-of-concept that frozen-thawed, ectopically autotransplanted adult human testicular tissue can support spermatogenesis in healthy adult men.
Trial Details
NCT Number NCT07364409
Lead Sponsor Herlev and Gentofte Hospital
Collaborators: University of Copenhagen, Rigshospitalet, Denmark
Conditions Cancer, Hematologic Diseases, Infertility, Male, Azoospermia, Nonobstructive
Enrollment 5 participants
Start Date 2024-11-04
Primary Completion 2025-12-17 (estimated)
Study Completion 2027-03 (estimated)
Updated on ClinicalTrials.gov 2026-01-23