Clinical Trial

Safety and Preliminary Efficacy of Hibernation-Like Therapy (Chlorpromazine and Promethazine) in Patients With Acute Ischemic Stroke (AIS) Eligible for Reperfusion Therapy.

Study acronym: CHILL-S
Not Yet Recruiting
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Record status
This record was last updated January 23, 2026 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a single-center, dose-escalation and dose-expansion Phase I study designed to evaluate the safety of hibernation-like therapy (Chlorpromazine and Promethazine, C+P) and observe improvements in infarct volume in patients with AIS eligible for reperfusion therapy.
Trial Details
NCT Number NCT07364344
Lead Sponsor Ji Xunming,MD,PhD
Conditions Acute Ischemic Stroke
Enrollment 57 participants
Start Date 2026-01
Primary Completion 2026-07 (estimated)
Study Completion 2026-07 (estimated)
Updated on ClinicalTrials.gov 2026-01-23