Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study

The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that includes comprehensive baseline and follow-up assessments at 3, 5, and 10 years. It comprises a main protocol and several optional modules, including a Cardiac Imaging Module, Biobanking Module, Pulmonary Module, and Anxiety and Depression Module. The study aims to advance understanding of cardiopulmonary and psychological comorbidities in rheumatoid arthritis, to improve early identification and management, and to enhance insights into underlying disease mechanisms-ultimately refining risk stratification and targeted prevention strategies. The study includes 4,000 patients with rheumatoid arthritis enrolled through the Cardiac Imaging Module in the main protocol. Participants undergo coronary computed tomography angiography, pulmonary function testing, physical examination, questionnaires, and biobanking, supplemented by genetic, proteomic, metabolomic, and microbiome profiling.

NCT Number	NCT07363980
Lead Sponsor	Ellen Margrethe Hauge Collaborators: University of Aarhus, Aarhus University Hospital, Independent Research Fund Denmark, Alfasigma S.p.A., ATACC-RD consortium, The Danish Rheumatism Association
Conditions	Rheumatoid Arthritis, Atherosclerotic Ischemic Disease, Pulmonary Disease, Depressive Disorder, Anxiety Disorders, Cardiovascular and Respiratory Disease, Cardiovascular Biomarkers, Cardiovascular (CV) Risk +9 more
Enrollment	4,000 participants
Start Date	2024-02-21
Primary Completion	2038-12-31 (estimated)
Study Completion	2040-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-03