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Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery

StatusRecruiting
PhaseEarly Phase 1
Started
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Record History

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  1. Primary completion pushed from Dec 1, 2027 to Dec 1, 2028v2 Show 5 more changesShow less
    • Recruitment opened
    • Start date changed from estimate of Jan 1, 2026 to Jul 1, 2026
    • Study completion pushed from Dec 31, 2027 to Dec 31, 2028
    • Site details revised at 4 of 4 sites
    • Study description shortened, about 1 word
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo. The study will include pregnant women aged 18-51 undergoing elective cesarean delivery at term (37 weeks or more). The main questions it aims to answer are: * Does topical TXA shorten uterine closure time? * Does topical TXA reduce the need for additional hemostatic sutures? Researchers will compare women receiving topical TXA to those receiving placebo (normal saline) to see if TXA reduces intraoperative bleeding and improves surgical outcomes. Participants will: * Be randomly assigned to receive either topical TXA or placebo during cesarean delivery. * Have standard surgery and postoperative care identical in both groups. * Provide routine clinical data, including hemoglobin levels and recovery outcomes, from their medical records.
Trial Details
NCT Number NCT07362992
Lead Sponsor Wolfson Medical Center
Collaborators: Rabin Medical Center, Meir Medical Center, Kaplan Medical Center
Conditions
(from sponsor)		 Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
Related terms Blood Loss, Surgical, Postpartum Hemorrhage
Enrollment 112 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov