Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse Headache

This study evaluates a novel treatment approach for medication overuse headache (MOH) using greater occipital nerve pulsed radiofrequency (GONPRF). Three treatment strategies are compared: Standard Treatment: Limitation of overused acute headache medications, lifestyle counseling, and continuation of existing preventive medications. Primary GONPRF: GONPRF administered in addition to standard treatment. Modified GONPRF: GONPRF administered as a second-line intervention in individuals who do not respond adequately to standard treatment alone. The study assesses whether GONPRF, when applied early or after an initial period of standard care, reduces monthly headache days more rapidly and effectively than standard treatment alone. Outcomes are evaluated over a 6-month follow-up period using headache diaries and scheduled clinical assessments. This is a randomized controlled trial designed to systematically evaluate the clinical benefit of GONPRF in patients with medication overuse headache.

NCT Number	NCT07360782
Lead Sponsor	Ankara City Hospital Bilkent
Conditions	Medication Overuse Headache
Enrollment	90 participants
Start Date	2026-01-26
Primary Completion	2026-12 (estimated)
Study Completion	2027-08 (estimated)
Updated on ClinicalTrials.gov	2026-01-27