High-Purity Type I Collagen Nerve Wrapping in Peripheral Nerve Procedures: A Prospective Registry

This prospective multicentre observational registry evaluates early clinical outcomes following the use of High-Purity Type I Collagen (HPTC) as a circumferential nerve wrap during peripheral nerve procedures. Eligible procedures include nerve repair, coaptation, grafting, nerve transfers, and decompressions in the upper and lower limbs. Primary outcomes include early motor recovery assessed using the Medical Research Council (MRC) motor grading system. Secondary outcomes include sensory recovery, neuropathic pain, patient-reported functional outcomes, complication rates, and patient satisfaction assessed at standardized postoperative intervals up to two months.

NCT Number	NCT07360730
Lead Sponsor	Adichunchanagiri Institute of Medical Sciences, B G Nagara Collaborators: Mysore Medical College and Research Institute
Conditions	Peripheral Nerve Injuries, Neuroma of Nerve Repair, Nerve Graft; Complications, Mechanical, Peripheral Nerve Decompression Injury, Neuroma
Enrollment	40 participants
Start Date	2025-12-09
Primary Completion	2026-02-26 (estimated)
Study Completion	2026-03-03 (estimated)
Updated on ClinicalTrials.gov	2026-03-30