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The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor

Study acronym: S100B-BDNF
StatusRecruiting
PhaseNot specified
Started
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Record status
This record was last updated April 15, 2026 (before its estimated April 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Recruitment opened
    • Study sites: 0 to 1
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive symptoms. Central sensitization is considered a key mechanism in the pathophysiology of fibromyalgia; however, the underlying biological markers have not been fully clarified. Brain-derived neurotrophic factor (BDNF) and S100B protein have been suggested to play roles in neuroinflammation and central pain processing. This observational, cross-sectional study aims to evaluate serum S100B and BDNF levels in patients with fibromyalgia and to investigate their relationship with central sensitization and sleep quality. Serum biomarker levels and clinical assessment scales will be compared between patients with fibromyalgia and healthy controls.
Trial Details
NCT Number NCT07358754
Lead Sponsor Kanuni Sultan Suleyman Training and Research Hospital
Conditions
(from sponsor)		 Fibromyalgia
Related terms Fibromyalgia
Enrollment 60 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov