Clinical Trial

B7-H3.CD28Z.CART in Solid Tumors

Not Yet Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
The goal of this research study is to test if a new cell therapy (B7-H3.CD28Z.CART / B7-H3 CAR T cells) is safe and effective in treating children and young adults with solid cancers whose tumors have returned or stopped responding to standard treatments (relapsed or refractory) and have been identified with a B7-H3 marker. The names of the treatment interventions used in this study are: * B7-H3.CD28Z.CART / B7-H3 CAR T cells * Fludarabine * Cyclophosphamide
Trial Details
NCT Number NCT07358260
Lead Sponsor Robbie Majzner
Collaborators: Band of Parents
Conditions Pediatric Solid Tumor, Neuroblastoma
Enrollment 40 participants
Start Date 2026-06
Primary Completion 2029-12-31 (estimated)
Study Completion 2031-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-01-22