Clinical Trial

Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen Extraction

Study acronym: NOSE
Not Yet Recruiting
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Record status
This record was last updated January 22, 2026 (before its estimated March 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
Natural Orifice Specimen Extraction (NOSE) eliminates the need for additional abdominal incisions in minimally invasive colorectal procedures, potentially reducing the risk of wound complications and postoperative pain. In the context of restorative Total Mesorectal Excision (TME), single-stapling (SS) techniques facilitate NOSE through transanal rectal transection, as opposed to the conventional double-stapling technique. This study aims to explore the potential advantages of NOSE combined with SS anastomosis compared to conventional abdominal extraction in minimally invasive restorative TME.
Trial Details
NCT Number NCT07358247
Lead Sponsor Istituto Clinico Humanitas
Conditions Rectal Cancer Patients, Rectal Cancer Surgery
Enrollment 190 participants
Start Date 2026-01-31
Primary Completion 2026-03-31 (estimated)
Study Completion 2026-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-01-22