Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia

This is a prospective, multicenter, interventional cohort study aimed at constructing a high-quality, dynamic multimodal database for patients with acute respiratory failure caused by community-acquired pneumonia (CAP-ARF). The study focuses on bacterial CAP-ARF patients receiving standardized glucocorticoid therapy to investigate the heterogeneity of treatment responses under different etiologies and immune statuses. The goal is to provide a data foundation for precise immune stratification and identification of glucocorticoid-sensitive populations.

NCT Number	NCT07357935
Lead Sponsor	Qingyuan Zhan Collaborators: The First Affiliated Hospital of Guangzhou Medical University, Wuhan Metware Biotechnology Co., Ltd.
Conditions	Acute Respiratory Failure, Community-Acquired Pneumonia
Enrollment	500 participants
Start Date	2026-02-01
Primary Completion	2028-09-01 (estimated)
Study Completion	2028-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-22