Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery

This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients undergoing supratentorial surgery. Propofol and remifentanil are administered using either target-controlled or manual infusion techniques according to the study protocol. Secondary objectives include comparisons of intraoperative anesthetic consumption, hemodynamic responses, recovery profiles, postoperative pain, and postoperative nausea and vomiting between the two anesthesia strategies. The study seeks to evaluate whether target-controlled infusion provides improved anesthetic management and postoperative outcomes compared with manual total intravenous anesthesia.

NCT Number	NCT07357480
Lead Sponsor	Istanbul University - Cerrahpasa
Conditions	Postoperative Delirium (POD), Postoperative Pain, PONV, Burst Suppression, Recovery Period, Anesthesia
Enrollment	70 participants
Start Date	2026-01-14
Primary Completion	2026-05 (estimated)
Study Completion	2026-05 (estimated)
Updated on ClinicalTrials.gov	2026-03-25