Carbon Dioxide Administration and Brain Waste Clearance

The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a counter-balanced design, in which individuals with and without a history of traumatic brain injury (TBI) will receive different levels of CO2 (targeted changes of approximately 5 or 10 mmHG in end-tidal CO2) approximately one week apart. The counter-balanced design means that each participant receives a single dose of CO2 at each visit, and different doses of CO2 at each visit. The order in which participants receive the dose is randomized, and the participant will not be informed of the dose.

NCT Number	NCT07357090
Lead Sponsor	Andrew Mayer
Conditions	Traumatic Brain Injury, Aging Disorder, Magnetic Resonance Imaging (MRI)
Enrollment	200 participants
Start Date	2026-04
Primary Completion	2031-01 (estimated)
Study Completion	2032-02 (estimated)
Updated on ClinicalTrials.gov	2026-02-23