AI-Enabled Electrocardiogram-Guided Guideline-Directed Medical Therapy on Incident Left Ventricular Dysfunction: A Target Trial Emulation Study

This multicenter retrospective study evaluates whether artificial intelligence-enabled electrocardiography (AI-ECG) can identify individuals at high risk for left ventricular dysfunction and whether targeted guideline-directed medical therapy can mitigate subsequent risk. Using a large multicenter cohort of patients with preserved left ventricular systolic function, the investigators applied an AI-ECG-based risk stratification approach and emulated a target trial to examine the association between guideline-directed therapies and the risk of incident left ventricular functional decline.

NCT Number	NCT07355023
Lead Sponsor	Tri-Service General Hospital
Conditions	Left Ventricular (LV) Systolic Dysfunction
Enrollment	5,000 participants
Start Date	2026-01-01
Primary Completion	2026-01-15 (estimated)
Study Completion	2026-01-15 (estimated)
Updated on ClinicalTrials.gov	2026-01-21