Selective Curettage and Tissue Adhesive in Endodontic Microsurgery

The goal of this randomized clinical trial is to determine whether selective curettage combined with cyanoacrylate tissue adhesive improves clinical outcomes in endodontic microsurgery compared with the conventional approach. The study purpose is to evaluate the postoperative healing associated with this conservative surgical protocol. The main questions it aims to answer are: Does selective curettage with tissue adhesive reduce postoperative pain, swelling, and complications compared to complete curettage with suturing? How does selective curettage affect clinical and radiographic healing of persistent periapical lesions? Researchers compared complete lesion curettage with suturing to selective curettage (40-70% lesion removal) with cyanoacrylate tissue adhesive closure to assess differences in healing and patient-related outcomes. Participants : Underwent endodontic microsurgery using one of the two surgical protocols Attended follow-up visits at 1, 3, and 7 days for clinical evaluation of pain, swelling ,Discomfort , Bleeding , Local reaction and Wound Dehiscence Attended follow-up visits at 3, 6, and 12 months for clinical and radiographic evaluation of periapical healing using 2D radiographs and CBCT

NCT Number	NCT07353580
Lead Sponsor	Mansoura University
Conditions	Healing and Patient Related Outcomes
Enrollment	24 participants
Start Date	2024-12-25
Primary Completion	2026-01-29 (estimated)
Study Completion	2026-02-27 (estimated)
Updated on ClinicalTrials.gov	2026-01-20