Clinical Trial

Standardized Management of Esophageal Fistula in Esophageal Squamous Cell Carcinoma

Study acronym: PKU-ESCC-EF
Not Yet Recruiting
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Record status
This record was last updated January 20, 2026 (before its estimated April 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
This prospective, multi-center, observational registry study (PKU-ESCC-EF) aims to evaluate the safety and effectiveness of a standardized diagnosis and treatment protocol for esophageal fistula (EF) in patients with advanced esophageal squamous cell carcinoma (ESCC). Esophageal fistula is a severe complication that often leads to life-threatening infections and poor nutrition. This study will observe patients receiving a comprehensive management strategy, which includes fistula sealing with esophageal or airway stents, targeted anti-infective therapy, nutritional support, and subsequent systemic anti-tumor therapy. The primary goal is to assess whether this standardized approach can improve overall survival and enable more patients to receive further anti-cancer treatments.
Trial Details
NCT Number NCT07353541
Lead Sponsor Peking University Cancer Hospital & Institute
Conditions Esophageal Squamous Cell Carcinoma (ESCC), Esophageal Fistula
Enrollment 32 participants
Start Date 2026-02-01
Primary Completion 2026-04-01 (estimated)
Study Completion 2026-04-01 (estimated)
Updated on ClinicalTrials.gov 2026-01-20