miR-342-5p/AnkG Pathway in Early AD Synaptic Dysfunction

Alzheimer's disease is the most common memory loss disease among the elderly. This disease affects the patient's memory, language, attention, and behavioral abilities. Current research has found that in the early stages of the disease, synaptic connections between brain nerve cells become abnormal, but the specific cause is still unclear. Investigators' previous research discovered that in the brains of diseased mice, certain special substances (the miR 342 5p/AnkG-mediated pathway) might be related to this abnormality, and these substances can be detected in both blood and cerebrospinal fluid. Therefore, investigators want to further explore the specific mechanisms of abnormal nerve cell connections, seek biomarkers for early detection of the disease, and provide new ideas for early diagnosis in the future.

NCT Number	NCT07353502
Lead Sponsor	The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Conditions	Alzheimer Disease, Biomarker in Early Diagnosis
Enrollment	40 participants
Start Date	2025-06-20
Primary Completion	2026-03-10 (estimated)
Study Completion	2026-03-10 (estimated)
Updated on ClinicalTrials.gov	2026-01-20