Clinical Trial

68Ga-Dotatate PET and MRI Guided Radiation Dose Escalation for High Risk Meningioma

Suspended Phase 1
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Why the trial stopped
dose escalation trial, and the first 3 patients (who made up a cohort) were all accrued
Summary
The is phase 1 trial of 68Ga-Dotatate PET/MRI guided radiation dose escalation for high-risk meningiomas (defined as recurrent or subtotal resection of Grade 2, and any Grade 3 meningioma). A modified toxicity probability interval schedule will be implemented with a Bayesian Optimal interval suite. It includes 4 dose cohort (66 Gy, 69 Gy, 72 Gy and 75 Gy). The initial study cohort will include 3 patients treated with 69 Gy in 30 daily fractions. The investigators will seek to determine the MTD of radiation therapy based DLTs.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-01-13.
Trial Details
NCT Number NCT07353229
Lead Sponsor Thomas Jefferson University
Conditions High Risk Meningioma, Recurrent Meningioma
Enrollment 24 participants
Start Date 2025-09-05
Primary Completion 2026-09 (estimated)
Study Completion 2028-09 (estimated)
Updated on ClinicalTrials.gov 2026-01-23