Clinical Trial

Reasoning Enrichment With Feedback From IA in NEphrology Trial

Study acronym: REFINe
Recruiting
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Summary
The goal of this clinical trial is to learn how artificial intelligence (AI) may help doctors make diagnoses in kidney medicine. The researchers want to know whether an AI tool called a large language model (LLM) can help doctors choose the correct diagnosis more often and feel more confident in their answers. Before starting the study, the research team tested several AI models and chose one of the best performers, a GPT-5-class model set to use high reasoning effort. The main questions this study aims to answer are: 1. Do doctors make more correct diagnoses when they can see AI suggestions? 2. Does seeing AI suggestions change how confident doctors feel about their diagnosis? Researchers will compare doctors who receive AI suggestions with doctors who do not receive AI suggestions to see how the AI affects accuracy, confidence, and decision-making. Participants will complete up to 10 online clinical cases. For each case, they will: 1. Read a short medical scenario 2. Suggest up to three possible diagnoses (If in the AI group) Review the AI's suggestions and decide whether to change their answer The study will also look at how long participants take to answer each case and how the AI's performance compares to the human answers.
Trial Details
NCT Number NCT07352475
Lead Sponsor University Hospital, Lille
Collaborators: Institut Pasteur de Lille, Lille University
Conditions Diagnosis, Clinical Decision-making, Artificial Intelligence (AI) in Diagnosis, Decision Support Systems, Clinical
Enrollment 100 participants
Start Date 2025-11-20
Primary Completion 2026-10-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-01-20