Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery

This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.

NCT Number	NCT07351149
Lead Sponsor	Uppsala University Collaborators: Uppsala University Hospital, Karolinska Institutet, Skane University Hospital, Karolinska University Hospital, Istituto Giannina Gaslini, Queen Silvia Children's Hospital, Gothenburg, Sweden, Feculdade de Medicina da Universidade de Sao Paulo - Brasil, University of Belgrade, University Hospital, Basel, Switzerland, Hospices Civils de Lyon, University of Bern, University Hospital, Geneva, Child and Adolescent Health Service - Perth
Conditions	Acute Kidney Injury
Enrollment	2,000 participants
Start Date	2026-03-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-12