Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty

The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN) block in participants undergoing total knee arthroplasty (TKA). The primary outcome is pain intensity, measured using the Numerical Rating Scale (NRS) at multiple time points after surgery. Secondary outcomes include opioid consumption, time to mobilization, postoperative nausea and vomiting, length of hospital stay, neurological complications and differences in opioid consumption and NRS pain scores between general and spinal anesthesia.

NCT Number	NCT07350252
Lead Sponsor	Region Skane Collaborators: Greta and Johan Kock Foundation
Conditions	Osteo Arthritis of the Knee
Enrollment	200 participants
Start Date	2026-03-05
Primary Completion	2027-03-01 (estimated)
Study Completion	2027-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-08