Clinical Trial

Botulinum Toxin A Facilitates Fascial Closure in Complex Incisional Hernias

Study acronym: BRIDGE-HERNIA
Completed
View on ClinicalTrials.gov →
Summary
Brief Study Description This prospective observational study evaluates the use of preoperative botulinum toxin A as part of a structured clinical pathway for patients undergoing elective repair of complex midline incisional hernias. Botulinum toxin A is administered before surgery to temporarily relax the abdominal wall muscles, with the aim of improving abdominal wall flexibility and facilitating closure of the hernia without the need for more extensive surgical techniques. The study collects clinical, radiological, and postoperative outcome data to assess surgical feasibility, complications, and early recurrence. The overall goal is to better understand how preoperative muscle relaxation may support safer and more effective abdominal wall reconstruction.
Trial Details
NCT Number NCT07349628
Lead Sponsor Azienda Sanitaria Locale Napoli 2 Nord
Conditions Incisional Hernia
Enrollment 32 participants
Start Date 2021-01-01
Primary Completion 2025-01-01 (estimated)
Study Completion 2025-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-01-20