Cold Plasma Effects on Dental Implant Stability

Cold plasma-mediated implant surface activation may reverse the biological aging of titanium by enhancing hydrophilicity and cellular response. The aim of this study was to clinically compare the effects of three different cold plasma systems on the stability of dental implants. In this prospective randomized controlled within-patient trial, a total of 44 implants were placed in 11 patients. In each patient, four implants were randomly allocated to one of the following groups: control, vacuum plasma, argon jet plasma, and cold atmospheric plasma. All implants were placed using a single-stage protocol with a minimum insertion torque of 45 Ncm. Implant stability was assessed using resonance frequency analysis (ISQ values) immediately after placement and at 2, 4, and 8 weeks.

NCT Number	NCT07348770
Lead Sponsor	Kahramanmaras Sutcu Imam University
Conditions	Cold Atmospheric Plasma, Dental Implants
Enrollment	11 participants
Start Date	2025-02-24
Primary Completion	2025-07-08 (estimated)
Study Completion	2025-09-09 (estimated)
Updated on ClinicalTrials.gov	2026-05-11