rFSH vs rFSH+rLH in Dydrogesterone-Based Progestin Protocol: A Prospective Study

This study aims to compare two commonly used hormone treatments for women undergoing IVF. All participants will receive a stimulation protocol that includes dydrogesterone, a medication used to safely control natural hormone surges during treatment. The study will observe women who are treated either with recombinant FSH alone or with a combination of recombinant FSH and recombinant LH-both routinely used options in our clinic. Investigators will prospectively monitor how these treatments affect the growth of ovarian follicles, the number of mature eggs collected, the quality of developing embryos, and early pregnancy outcomes. No additional procedures or medications will be required beyond standard IVF care. The goal is to better understand whether adding recombinant LH provides any measurable benefit in dydrogesterone-based PPOS cycles.

NCT Number	NCT07348757
Lead Sponsor	Centrum Clinic IVF Center
Conditions	InVitro Fertilization, Gonadotropins
Enrollment	202 participants
Start Date	2026-02-05
Primary Completion	2026-06-15 (estimated)
Study Completion	2026-06-20 (estimated)
Updated on ClinicalTrials.gov	2026-06-24