Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine and Nicotine Analogues

Electronic cigarettes are battery-operated devices that can produce an aerosol by heating a liquid which commonly contains nicotine. In recent years, products containing synthetically produced nicotine and nicotine analogues have entered the market. However, it remains unclear whether these types of nicotine have the same effects as conventional nicotine derived from the tobacco plant. The aim of this study is to investigate the effects of these nicotine types and to gain a better understanding of their respective mechanisms of action.

NCT Number	NCT07348224
Lead Sponsor	Insel Gruppe AG, University Hospital Bern Collaborators: Swiss Tobacco Prevention Funds
Conditions	Nicotine, Vaping, Synthetic Nicotine, Nicotine Analogues
Enrollment	24 participants
Start Date	2026-08-05
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-06