Clinical Trial

Intra-operative Hypotension and Post-operative Lactate Level After Pancreatic-duodenectomy

Study acronym: HYPOL
Enrolling by Invitation
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Record status
This record was last updated June 25, 2026 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Intraoperative hypotension is a frequent occurrence during pancreaticoduodenectomy (PD) and has been associated with impaired tissue perfusion and organ dysfunction. However, its specific relationship with early postoperative hyperlactatemia and clinical outcomes inpancreaticoduodenectomy (PD) patients remains poorly characterized. Identifying a correlation between time-weighted average hypotension (TWA65) and postoperative lactate levels could provide valuable insights for optimizing intraoperative hemodynamic management and improving postoperative outcomes in high-risk abdominal surgery.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-01-08.
Trial Details
NCT Number NCT07346274
Lead Sponsor Istituto Clinico Humanitas
Conditions Serum Lactate Post-pancreatic Duodenectomy
Enrollment 60 participants
Start Date 2026-01-07
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-07-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-25