Clinical Trial

Postoperative Complications After Neoadjuvant Chemoradiotherapy or Short-course Radiotherapy and Total Neoadjuvant Treatment: a Multicentric Retrospective Cohort Study

Study acronym: POCAT
Enrolling by Invitation
View on ClinicalTrials.gov →
Record status
This record was last updated January 16, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The primary objective of the study is to compare the rate of postoperative complications between rectal cancer patients undergoing standard neoadjuvant chemoradiotherapy or short- course radiotherapy and patients receiving TNT. The secondary objectives of the study include the evaluation of treatment-related adverse reactions and postoperative complications in elderly patients receiving the treatments and the comparison of treatment-related adverse reactions and postoperative complications in patients receiving induction versus consolidation TNT.
Trial Details
NCT Number NCT07346248
Lead Sponsor Istituto Clinico Humanitas
Conditions Adult Patients With Locally Advanced Rectal Cancer Indicated to Neoadjuvant Therapy and Surgery
Enrollment 266 participants
Start Date 2025-07-21
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-01-16